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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K5
All Species:
13.33
Human Site:
T235
Identified Species:
29.33
UniProt:
Q99683
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99683
NP_005914.1
1374
154537
T235
S
S
F
M
K
G
L
T
E
L
M
Q
P
N
F
Chimpanzee
Pan troglodytes
XP_001171211
1375
154924
T236
S
S
F
M
K
G
L
T
E
L
M
Q
P
N
F
Rhesus Macaque
Macaca mulatta
XP_001111127
1297
143635
L220
L
T
P
L
V
G
R
L
A
R
L
L
E
A
T
Dog
Lupus familis
XP_533420
1645
181128
P476
M
S
D
A
F
R
Q
P
S
L
F
Y
H
L
G
Cat
Felis silvestris
Mouse
Mus musculus
O35099
1380
154441
T242
S
S
F
M
K
G
L
T
E
L
M
Q
P
N
F
Rat
Rattus norvegicus
XP_001073260
1338
150427
C221
E
L
L
L
G
P
I
C
L
P
L
V
D
R
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511920
1243
141469
V220
D
L
A
S
H
H
H
V
K
F
H
Y
A
F
A
Chicken
Gallus gallus
XP_419725
1260
143069
V220
Y
D
S
I
V
K
L
V
K
T
L
E
K
L
P
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001155222
1364
153160
S222
S
S
L
M
K
G
L
S
E
L
M
Q
P
S
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477089
1363
155478
R220
H
S
F
M
C
S
L
R
D
V
Q
D
Y
D
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001202919
1288
145042
F221
S
G
D
I
V
H
Q
F
L
L
S
Y
R
E
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
44.9
68
N.A.
94.1
92.7
N.A.
84.4
80.4
N.A.
71.7
N.A.
40.6
N.A.
N.A.
44.6
Protein Similarity:
100
99.4
61.3
73.1
N.A.
95.8
94.4
N.A.
87.8
87
N.A.
84.1
N.A.
58.2
N.A.
N.A.
60.7
P-Site Identity:
100
100
6.6
13.3
N.A.
100
6.6
N.A.
0
6.6
N.A.
80
N.A.
26.6
N.A.
N.A.
13.3
P-Site Similarity:
100
100
26.6
13.3
N.A.
100
26.6
N.A.
6.6
33.3
N.A.
93.3
N.A.
46.6
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
10
0
0
0
0
10
0
0
0
10
10
19
% A
% Cys:
0
0
0
0
10
0
0
10
0
0
0
0
0
0
0
% C
% Asp:
10
10
19
0
0
0
0
0
10
0
0
10
10
10
0
% D
% Glu:
10
0
0
0
0
0
0
0
37
0
0
10
10
10
0
% E
% Phe:
0
0
37
0
10
0
0
10
0
10
10
0
0
10
46
% F
% Gly:
0
10
0
0
10
46
0
0
0
0
0
0
0
0
10
% G
% His:
10
0
0
0
10
19
10
0
0
0
10
0
10
0
0
% H
% Ile:
0
0
0
19
0
0
10
0
0
0
0
0
0
0
10
% I
% Lys:
0
0
0
0
37
10
0
0
19
0
0
0
10
0
0
% K
% Leu:
10
19
19
19
0
0
55
10
19
55
28
10
0
19
0
% L
% Met:
10
0
0
46
0
0
0
0
0
0
37
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
28
0
% N
% Pro:
0
0
10
0
0
10
0
10
0
10
0
0
37
0
10
% P
% Gln:
0
0
0
0
0
0
19
0
0
0
10
37
0
0
0
% Q
% Arg:
0
0
0
0
0
10
10
10
0
10
0
0
10
10
0
% R
% Ser:
46
55
10
10
0
10
0
10
10
0
10
0
0
10
0
% S
% Thr:
0
10
0
0
0
0
0
28
0
10
0
0
0
0
10
% T
% Val:
0
0
0
0
28
0
0
19
0
10
0
10
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
0
0
0
0
0
0
0
0
0
28
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _